Dr. Mefloquine‐Induced Eosinophilic Pneumonia
Identifieur interne : 001B54 ( Main/Exploration ); précédent : 001B53; suivant : 001B55Dr. Mefloquine‐Induced Eosinophilic Pneumonia
Auteurs : Stamatis Katsenos [Grèce] ; Kostas Psathakis [Grèce] ; Melita I. Nikolopoulou [Grèce] ; Stavros H. Constantopoulos [Grèce]Source :
- Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy [ 0277-0008 ] ; 2007-12.
English descriptors
- Teeft :
- Alveolar macrophages, Aminobutyric acid release, Antimalarial, Antimalarial agent, Arterial blood gases, Bronchoalveolar lavage, Chest radiography, Clin, Eosinophil, Eosinophilia, Eosinophilic, Eosinophilic lung disease, Eosinophilic pneumonia, Eosinophilic pneumonia katsenos, Infiltrates, Katsenos, Ketoconazole, Malaria prophylaxis, Mefloquine, Musculoskeletal manifestations, Oral mefloquine, Partial pressure, Peripheral blood eosinophilia, Pharmacotherapy volume, Plasmodium, Pneumonia, Prophylaxis, Pulmonary eosinophilia, Pulmonary toxicity, Radiography, Subpleural infiltrates, Tomography, Tomography scan, Topical ketoconazole, Toxicity, University hospital.
Abstract
Mefloquine has been widely used for prophylaxis and treatment of patients with chloroquine‐resistant malaria; the drug is usually well tolerated. Rarely, adverse effects may be severe, including gastrointestinal disturbances, neuropsychiatric reactions, cardiovascular manifestations, skin lesions, musculoskeletal symptoms, and bone marrow toxicity. We describe a 67‐year‐old woman with fever, dyspnea on exertion, peripheral blood eosinophilia, and diffuse pulmonary infiltrates on chest radiography. She had taken mefloquine for malaria prophylaxis for an 8‐week trip to South Africa. A thorough work‐up led to the diagnosis of eosinophilic pneumonia caused by the mefloquine. Her condition improved after the drug was discontinued. To our knowledge, this is the first report of mefloquine‐induced eosinophilic pneumonia. Clinicians should be aware of this rare, potential adverse effect of mefloquine.
Url:
DOI: 10.1592/phco.27.12.1767
Affiliations:
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Constantopoulos</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Pneumonology, University Hospital, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy</title><title level="j" type="alt">PHARMACOTHERAPY: THE JOURNAL OF HUMAN PHARMACOLOGY AND DRUG THERAPY</title><idno type="ISSN">0277-0008</idno><idno type="eISSN">1875-9114</idno><imprint><biblScope unit="vol">27</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1767">1767</biblScope><biblScope unit="page" to="1771">1771</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2007-12">2007-12</date></imprint><idno type="ISSN">0277-0008</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0277-0008</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Alveolar macrophages</term><term>Aminobutyric acid release</term><term>Antimalarial</term><term>Antimalarial agent</term><term>Arterial blood gases</term><term>Bronchoalveolar lavage</term><term>Chest radiography</term><term>Clin</term><term>Eosinophil</term><term>Eosinophilia</term><term>Eosinophilic</term><term>Eosinophilic lung disease</term><term>Eosinophilic pneumonia</term><term>Eosinophilic pneumonia katsenos</term><term>Infiltrates</term><term>Katsenos</term><term>Ketoconazole</term><term>Malaria prophylaxis</term><term>Mefloquine</term><term>Musculoskeletal manifestations</term><term>Oral mefloquine</term><term>Partial pressure</term><term>Peripheral blood eosinophilia</term><term>Pharmacotherapy volume</term><term>Plasmodium</term><term>Pneumonia</term><term>Prophylaxis</term><term>Pulmonary eosinophilia</term><term>Pulmonary toxicity</term><term>Radiography</term><term>Subpleural infiltrates</term><term>Tomography</term><term>Tomography scan</term><term>Topical ketoconazole</term><term>Toxicity</term><term>University hospital</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mefloquine has been widely used for prophylaxis and treatment of patients with chloroquine‐resistant malaria; the drug is usually well tolerated. Rarely, adverse effects may be severe, including gastrointestinal disturbances, neuropsychiatric reactions, cardiovascular manifestations, skin lesions, musculoskeletal symptoms, and bone marrow toxicity. We describe a 67‐year‐old woman with fever, dyspnea on exertion, peripheral blood eosinophilia, and diffuse pulmonary infiltrates on chest radiography. She had taken mefloquine for malaria prophylaxis for an 8‐week trip to South Africa. A thorough work‐up led to the diagnosis of eosinophilic pneumonia caused by the mefloquine. Her condition improved after the drug was discontinued. To our knowledge, this is the first report of mefloquine‐induced eosinophilic pneumonia. Clinicians should be aware of this rare, potential adverse effect of mefloquine.</div></front></TEI><affiliations><list><country><li>Grèce</li></country><region><li>Attique (région)</li></region><settlement><li>Athènes</li></settlement></list><tree><country name="Grèce"><noRegion><name sortKey="Katsenos, Stamatis" sort="Katsenos, Stamatis" uniqKey="Katsenos S" first="Stamatis" last="Katsenos">Stamatis Katsenos</name></noRegion><name sortKey="Constantopoulos, Stavros H" sort="Constantopoulos, Stavros H" uniqKey="Constantopoulos S" first="Stavros H." last="Constantopoulos">Stavros H. Constantopoulos</name><name sortKey="Katsenos, Stamatis" sort="Katsenos, Stamatis" uniqKey="Katsenos S" first="Stamatis" last="Katsenos">Stamatis Katsenos</name><name sortKey="Nikolopoulou, Melita I" sort="Nikolopoulou, Melita I" uniqKey="Nikolopoulou M" first="Melita I." last="Nikolopoulou">Melita I. Nikolopoulou</name><name sortKey="Psathakis, Kostas" sort="Psathakis, Kostas" uniqKey="Psathakis K" first="Kostas" last="Psathakis">Kostas Psathakis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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